9797. ALEX3 test (molecular analysis for 300 allergens, IgE antibodies)

ALEX³ (Allergy Explorer) is a modern third-generation multiplex in vitro allergy test that enables simultaneous determination of total IgE and specific IgE to 300 allergens from 145 sources. The test is based on patented nanotechnology that helps diagnose existing or hidden allergic sensitization. Compared to the previous version of the test, ALEX³ contains an expanded panel of modern molecular components, which increases the accuracy and clinical informativeness of the results.

ALEX³ is a modern laboratory test for comprehensive allergy diagnostics. It enables evaluation of sensitivity to a large number of food, pollen, household, fungal, and animal allergens within a single test.

Unlike standard allergy panels, ALEX³ analyzes not only the source of the allergy but also individual molecular allergen components. This helps more accurately identify the true cause of symptoms, assess the risk of severe reactions, and reduce the impact of cross-reactivity.

The expanded ALEX³ panel includes modern markers, in particular:

• components associated with cross-reactive allergic responses between pollen, fruits, vegetables, and other allergens;
• the α-Gal component, which helps identify a rare form of delayed allergy to red meat;
• components associated with the risk of severe allergic reactions to certain foods, particularly peach;
• additional mold, mite, insect, pollen, and animal allergens that allow a more accurate assessment of the allergic sensitization profile, taking into account lifestyle, occupational, and geographic factors.

The updated version of the test helps assess the risk of systemic allergic reactions, including anaphylaxis, and is useful for people with multiple allergic sensitivities when conventional skin tests do not always clearly identify the clinically significant allergen.

Capabilities of ALEX³

ALEX³ allows:

• distinguishing true allergy from cross-reactive sensitization;
• clarifying the cause of allergic symptoms;
• assessing the risk of severe allergic reactions;
• avoiding unjustified dietary or household restrictions;
• assisting in the selection of allergen-specific immunotherapy (AIT);
• creating a personalized treatment approach.

The test may be recommended for adults and children:

• with multiple allergic sensitivities;
• with conflicting results of skin tests or other allergy investigations;
• with combined allergic manifestations (atopic dermatitis, allergic rhinitis, bronchial asthma, food allergy);
• with severe or unexplained allergic reactions, including a history of anaphylaxis;
• with suspected food allergy or α-Gal syndrome;
• before starting allergen-specific immunotherapy (AIT).

• Venous blood

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules: