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  4. 9700. 1,25-dihydroxyvitamin D, 1,25-(OH)2D

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9700. 1,25-dihydroxyvitamin D, 1,25-(OH)2D

9700. 1,25-dihydroxyvitamin D, 1,25-(OH)2D

Turnaround time (days): 14

2840 ₴

Important information

*The test is performed at Synevo laboratory in Germany

Description

1,25-Dihydroxyvitamin D (1,25-(OH)₂D, calcitriol) is the biologically active form of vitamin D. Vitamin D plays an important role in calcium and phosphorus metabolism, modulation of cell growth, neuromuscular function, immune response, and inflammation.

This test is used as a second-line assessment of vitamin D status, particularly in patients with kidney disease, sarcoidosis, and hypoparathyroidism.

Vitamin D is a general term for a group of fat-soluble, structurally related sterols that function as hormones. It is obtained from foods of plant and animal origin and can also be synthesized in the skin following ultraviolet (UV) exposure. The initial test for assessing vitamin D status, which most accurately reflects the body's vitamin D stores, is 25-hydroxyvitamin D (25(OH)D).

25(OH)D is a prohormone, the primary storage and transport form of vitamin D. It is stored in adipose tissue and circulates tightly bound to a transport protein. However, in patients with kidney disease or hypercalcemia, measurement of 1,25-dihydroxyvitamin D may be required for a more accurate assessment of vitamin D status.

1,25-Dihydroxyvitamin D stimulates intestinal calcium absorption, and its production is regulated by serum calcium, phosphorus, and parathyroid hormone concentrations. Levels of 1,25-dihydroxyvitamin D are decreased in chronic kidney disease and hypoparathyroidism, and increased in sarcoidosis and other granulomatous diseases, certain malignancies, and primary or secondary hyperparathyroidism.

The concentration of 1,25-dihydroxyvitamin D is not a reliable indicator of vitamin D toxicity. In such cases, normal or even decreased levels may be observed.

When and who needs the test?

  • As a second-line test for assessing vitamin D status, particularly in patients with kidney disease.
  • For the evaluation of selected patients with clinical signs of vitamin D deficiency (e.g., vitamin D-dependent rickets caused by inherited renal 1-alpha-hydroxylase deficiency or target-organ resistance to 1,25-dihydroxyvitamin D).
  • For the differential diagnosis of hypercalcemia.

Biological material

  • Venous blood

Preparing for a blood test

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:

  • an important condition for laboratory tests is to take blood on an empty stomach;
  • 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...

9700. 1,25-dihydroxyvitamin D, 1,25-(OH)2D

2840 ₴

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