9206. Tumor marker protein S-100

S-100 is a protein synthesized by nerve cells and melanocytes. Elevated levels in the blood may indicate damage to the central nervous system or the development of melanoma. The test is used to assess the condition of neurological, oncological, and autoimmune diseases.

The S-100 tumor marker is a protein belonging to the group of calcium-binding proteins synthesized by nervous tissue cells, melanocytes, and some immune cells.

Its determination in serum is used for:

• diagnosing melanoma – for detection, treatment monitoring, and recurrence prediction;
• assessing the severity of CNS damage in traumatic brain injury, ischemia, and neonatal asphyxia;
• monitoring neurodegenerative diseases (Alzheimer's, Parkinson's);
• assessing the inflammatory process in systemic autoimmune diseases (SLE, rheumatoid arthritis, psoriasis).

S-100 protein levels may also increase in:

• acute heart failure or ischemia;
• epilepsy and multiple sclerosis;
• stroke or cerebral hemorrhage.

• individuals with neurological symptoms, after traumatic brain injury, or in a coma;
• patients with cardiovascular pathology for differential diagnosis;
• newborns after hypoxic conditions or birth trauma;
• in systemic autoimmune diseases to control inflammatory activity.

• Venous blood

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules: