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  4. 9169. Gliadin, IgG antibodies

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9169. Gliadin, IgG antibodies

9169. Gliadin, IgG antibodies

Turnaround time (days): 1

930 ₴

Description

IgG antibodies to gliadin appear when gluten enters the gastrointestinal tract in predisposed individuals and are a marker of gluten-sensitive enteropathy. This condition may manifest with symptoms such as vomiting, abdominal pain, dermatitis, anemia, visual disturbances, and epilepsy.

Testing for these antibodies is used to diagnose gluten-sensitive enteropathy and assess the effectiveness of a gluten-free diet. It is also used as a screening method during evaluation for type 1 diabetes mellitus and Hashimoto’s autoimmune thyroiditis.

The test is usually performed as part of a panel that includes testing for IgA antibodies to gliadin, antibodies to tissue transglutaminase, and antibodies to endomysium.

Gluten-sensitive enteropathy is a multifactorial disease with a strong genetic predisposition. Its prevalence among close relatives of patients with celiac disease is 10%, which is significantly higher than in the general population (≈1%). Gluten is found in the grains of wheat, rye, barley, oats, and certain other cereals.

Gliadins are a group of alcohol-soluble proteins that are components of gluten in cereal grains and can trigger an immune response, accompanied by the production of specific antigliadin antibodies (AGA), which initiate an inflammatory reaction and lead to atrophy of the small intestinal mucosa.

Determination of antigliadin antibodies is an important screening tool for first-degree relatives of patients with celiac disease and for individuals with associated conditions such as type 1 diabetes mellitus, Hashimoto’s autoimmune thyroiditis, Down syndrome, and systemic connective tissue diseases, with the aim of early detection of the disease.

When and who needs the test?

  • Screening of patients with suspected celiac disease (with typical or atypical clinical presentations) and individuals at increased risk of developing the disease.
  • To monitor the effectiveness of treatment with a gluten-free diet.

Biological material

  • Venous blood

Preparing for a blood test

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:

  • an important condition for laboratory tests is to take blood on an empty stomach;
  • 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...

9169. Gliadin, IgG antibodies

930 ₴

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