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  3. 4016. Anti-Rhesus alloimmune antibodies (anti-erythrocyte alloimmune antibodies in the indirect Coombs test)

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4016. Anti-Rhesus alloimmune antibodies (anti-erythrocyte alloimmune antibodies in the indirect Coombs test)

4016. Anti-Rhesus alloimmune antibodies (anti-erythrocyte alloimmune antibodies in the indirect Coombs test)

Термін_виконання: 1

745 ₴

Важлива_інформація

*The test is recommended for women who are Rh negative

Опис

Anti-Rh alloimmune antibodies are immunoglobulins produced by the body in response to exposure to red blood cell (RBC) antigens that differ from the individual’s own, most commonly Rh system antigens. These antibodies are usually detected using the Indirect Coombs Test. This test is critically important during pregnancy, before a blood transfusion, and after one has been given.

Anti-Rh alloantibodies (alloantibodies) are specific immunoglobulins (primarily IgG) produced by Rh-negative individuals after immunization with Rh system antigens (most commonly the D antigen) due to the entry of Rh-positive red blood cells into the circulation. This may occur during pregnancy, childbirth, blood transfusion, or other invasive procedures.

The test is performed using the Indirect Antiglobulin Test (IAT), also known as the Indirect Coombs Test. This method detects circulating anti-erythrocyte antibodies in plasma that are not bound to the patient's own red blood cells but can react with corresponding donor or fetal red blood cell antigens.

Clinical significance

The primary purpose of this test is to assess the risk of hemolytic disease of the fetus and newborn (HDFN), which can develop due to transplacental passage of maternal antibodies and subsequent destruction of fetal red blood cells.

The test is also used in transfusion medicine to detect antibodies in patients undergoing or having undergone blood or blood component transfusion.

Коли_кому

When?

  • In the first trimester of pregnancy and throughout the course of pregnancy.
  • After potentially sensitizing events such as bleeding, amniocentesis, external cephalic version, abdominal trauma, or miscarriage.
  • Before and after a blood transfusion.
  • In cases of complicated obstetric history, such as previous unexplained pregnancy loss or placental insufficiency.

Who?

  • Pregnant women with Rh(D)-negative status.
  • Patients receiving blood transfusions, especially those who are Rh(D)-negative.

Біоматеріал

  • Venous blood

Preparing for a blood test

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:

  • an important condition for laboratory tests is to take blood on an empty stomach.
  • 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...

4016. Anti-Rhesus alloimmune antibodies (anti-erythrocyte alloimmune antibodies in the indirect Coombs test)

745 ₴

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0 800 60 55 00

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Сінево, 2026