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  4. 3104. Package # 190 (PCR. Genetics. Folate cycle)

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3104. Package # 190 (PCR. Genetics. Folate cycle)

3104. Package # 190 (PCR. Genetics. Folate cycle)

Number of tests: 4
PCR. Folate cycle. MTRR (66 A>G)
PCR. Folate cycle. MTHFR (677 C>T)

Turnaround time (days): 3

1510 ₴

Description

A comprehensive genetic test that assesses the status of the folate cycle, an important process involved in folic acid metabolism. Impairments in this cycle may lead to hyperhomocysteinemia and an increased risk of pregnancy complications, cardiovascular diseases, and cancer.

The folate cycle is one of the key biochemical pathways involved in DNA synthesis, homocysteine metabolism, blood cell formation, and nervous system function. Disruptions in this cycle occur as a result of polymorphisms in the MTHFR, MTRR, and MTR genes, which affect the conversion of folic acid into its active form and the detoxification of homocysteine.

Elevated homocysteine levels (hyperhomocysteinemia), which often occur with these genetic changes, are considered a risk factor for:

  • thrombosis and cardiovascular events;
  • neural tube defects in the fetus;
  • impaired fertility;
  • adverse pregnancy outcomes;
  • cancer (due to DNA methylation);
  • impaired cognitive function and neurological diseases.

When and who needs the test?

  • During preconception planning or early pregnancy.
  • A history of recurrent pregnancy loss or fetal malformations in previous pregnancies.
  • When planning IVF or other assisted reproductive technologies (ART).
  • A personal or family history of thrombophilia.
  • A history of early myocardial infarction, stroke, or venous thrombosis.
  • Cancer diagnosed at a young age.
  • Hyperhomocysteinemia identified by biochemical testing.

Biological material

  • Venous blood

Preparing for a blood test

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:

  • an important condition for laboratory tests is to take blood on an empty stomach;
  • 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...

3104. Package # 190 (PCR. Genetics. Folate cycle)

1510 ₴

Information service

0 800 60 55 00

Free from mobile and stationary operators in Ukraine (except for the temporarily occupied territories)

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