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  4. 2227. Myositis profile (BlotAnalisis)

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2227. Myositis profile (BlotAnalisis)

2227. Myositis profile (BlotAnalisis)

Turnaround time (days): 2

2440 ₴

Important information

*IgG antibodies: Mi-2 (marker for idiopathic myositis), Ku (marker for the combination of scleroderma and polymyositis), PM-Scl complex, scleroderma marker; histidyl-tRNA synthetase (Jo-1), threonyl-tRNA synthetase (PL-7), alanyl-tRNA synthetase (PL-12), Ring-dependent E3 ligase (Ro-52).

Description

Myositis-specific autoantibodies target various proteins in skeletal muscle cells and contribute to the development of autoimmune myositis.

Testing for these antibodies is indicated when symptoms such as muscle pain and weakness, swelling, skin lesions, or recurrent fever occur.

The test is performed for the diagnosis and differential diagnosis of myositis (dermatomyositis, polymyositis, and myositis).

The test is usually performed as part of a panel that includes blood biochemistry, electrolyte testing, creatine kinase (CK), myoglobin, and antinuclear antibodies (ANA).

The most common subtypes are inclusion body myositis (IBM), polymyositis (PM), dermatomyositis (DM), and immune-mediated necrotizing myopathy (IMNM). Myositis may be a manifestation of generalized connective tissue involvement. In antisynthetase syndrome associated with polymyositis, interstitial lung disease, arthritis, fever, and Raynaud’s syndrome may occur in addition to myositis.

Detection of specific antibodies helps differentiate between types of myositis and assess the likelihood of concomitant autoimmune diseases. Immunoblot analysis is highly sensitive for antisynthetase syndrome and dermatomyositis.

When and who needs the test?

  • For screening for autoimmune myopathies in patients with muscle weakness, muscle pain, or elevated creatine kinase (CK) levels.
  • For monitoring disease course and assessing treatment efficacy.
  • For the differential diagnosis of different types of myositis and other autoimmune disorders.

Biological material

  • Venous blood

Preparing for a blood test

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:

  • an important condition for laboratory tests is to take blood on an empty stomach;
  • 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...

2227. Myositis profile (BlotAnalisis)

2440 ₴

Information service

0 800 60 55 00

Free from mobile and stationary operators in Ukraine (except for the temporarily occupied territories)

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