2175. Package # 5.10 (Systemic vasculitis - ANCA)

This is a comprehensive test used for the diagnosis of autoimmune vasculitides, particularly those associated with antineutrophil cytoplasmic antibodies (ANCA). The panel includes testing for IgG antibodies to the glomerular basement membrane (GBM), myeloperoxidase (MPO), and proteinase 3 (PR3).

The panel is used for the diagnosis and detection of autoimmune diseases affecting small-caliber blood vessels, including granulomatosis with polyangiitis (Wegener’s granulomatosis), microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome), and rapidly progressive glomerulonephritis.

Symptoms of the disease include fever, weight loss, unexplained weakness, skin rashes, Raynaud’s syndrome, nosebleeds, cough with bloody sputum, hematuria, hypertension, headache, focal neurological symptoms, seizures, and others.

The panel enables the differential diagnosis of systemic vasculitides and assessment of disease severity in rapidly progressive glomerulonephritis.

Testing for ANCA-associated antibodies has high diagnostic value for the detection of systemic vasculitides such as granulomatosis with polyangiitis (Wegener’s granulomatosis), microscopic polyangiitis, and Goodpasture syndrome.

• The panel is recommended for patients with acute inflammatory manifestations involving the kidneys and vascular system.
• For screening for autoimmune vasculitides in patients with fever of unknown origin, renal involvement, or pulmonary symptoms.
• For monitoring disease course and assessing treatment efficacy.
• For the differential diagnosis of different types of vasculitis and other autoimmune disorders.

• Venous blood

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules: