2126. Bordetella pertussis, IgM antibodies

A serological test that detects IgM antibodies to pertussis toxin, a protein produced by the Bordetella pertussis bacterium and the main factor in the development of whooping cough symptoms. IgM antibodies appear early in the infection and persist for a short time. A positive result indicates an active or recent infection, especially in cases of persistent coughing.

Whooping cough is an acute bacterial respiratory disease caused by Bordetella pertussis. It is transmitted by airborne droplets and is highly contagious, especially in groups and among unvaccinated individuals.

The classic symptoms of whooping cough include coughing fits, loud, deep inhalations between coughs, and post-cough vomiting. The course of the disease is divided into three phases: catarrhal (with acute respiratory viral infection symptoms), spasmodic (with a typically prolonged cough with paroxysms), and convalescence. It is especially dangerous for infants and individuals with weakened immune systems.

IgM antibodies begin to be synthesized within two weeks after the onset of clinical signs in response to Bordetella pertussis infection. Serological testing is more useful for children and adults with symptoms that last more than three weeks. Detection of IgM antibodies may indicate a recent or active infection.

• For children and adults with suspected whooping cough (paroxysmal cough lasting more than 3 weeks).
• For differential diagnosis with acute respiratory infections.
• For individuals who have had contact with patients with whooping cough.
• For the diagnosis of post-infection and post-vaccination immune responses.

• Venous blood

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules: