2118. β-2-glycoprotein I, IgA antibodies

β-2-glycoprotein I is a glycosylated plasma protein with anticoagulant properties.

A test for the determination of antibodies to it is used to diagnose antiphospholipid syndrome in case of pathology of pregnancy, before taking oral contraceptives, oncology, a decrease in platelets, stroke or myocardial infarction. APS manifests itself in the form of venous thrombosis, pulmonary hypertension, migraine, seizures, mental disorders.

An increase in IgA antibodies indicates an acute course of the disease. In the complex, a general analysis, a biochemical blood test, a coagulogram, antibodies to cardiolipin are prescribed.

Exclusion of APS as one of the forms of thrombophilia (especially at a young age) with:

• venous/arterial thrombosis (deep vein thrombosis, myocardial infarction, stroke, pulmonary embolism, visceral infarction, livedo reticularis, leg ulcers, transient cerebrovascular accident, etc.)
• miscarriage, fetal loss syndrome at different times, infertility, bleeding during pregnancy, development of pre- and eclampsia, placental insufficiency with IUGR of the fetus, premature placental abruption (PVNRP), stillbirths
• before you start taking OK, HRT and to control when taking these drugs
• in cardiovascular pathology to assess the risk of development or cause of thrombotic complications (stroke, heart attack)
• autoimmune diseases
• any oncopathology
• detection of APTT elongation in the coagulogram
• negative results of other laboratory markers of APS
• HELLP-syndrome
• positive Wasserman reaction (RW)
• thrombocytopenia, hemolytic anemia

Retesting after a positive primary result to establish a diagnosis (after 12 weeks).

• Venous blood

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules: