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2108. Tissue transglutaminase, IgG antibodies
Description
IgG antibodies to tissue transglutaminase (tTG-IgG) are a serological marker used in the diagnosis of celiac disease, particularly in individuals with IgA deficiency or atypical clinical manifestations of the disease, such as chronic diarrhea, anemia, osteoporosis, or neurological disorders. An elevated level of IgG-tTG indicates a high likelihood of celiac disease.
A normal level does not exclude the disease, particularly in the presence of clinical symptoms. IgG antibody levels to tissue transglutaminase decrease when a gluten-free diet is followed.
When and who needs the test?
- Screening of patients with suspected celiac disease (with a typical or atypical clinical presentation) and individuals at increased risk of developing the disease (a family history of celiac disease, a preliminary diagnosis, carriers of HLA-DQ2 and/or HLA-DQ8 alleles).
- Screening in patients with suspected dermatitis herpetiformis, in conjunction with anti-endomysial antibody testing, for monitoring disease activity, assessing adherence to a gluten-free diet, and monitoring compliance with a gluten-free diet in patients with dermatitis herpetiformis and celiac disease.
Biological material
- Venous blood
Preparing for a blood test
In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:
- an important condition for laboratory tests is to take blood on an empty stomach;
- 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...
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