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  4. 2094. Tumor marker HE4

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2094. Tumor marker HE4

2094. Tumor marker HE4

Turnaround time (days): 1

890 ₴

Description

HE4 is a tumor marker used for the diagnosis, prognosis, and treatment monitoring of ovarian and endometrial cancer. Elevated HE4 levels are characteristic of epithelial tumors, even with a normal CA 125 level.

HE4 (Human Epididymis Protein 4) is a small glycoprotein from a family of proteins with four-disulfide bonds in their structure. Its normal function is not fully understood, but HE4 is believed to play a role in protecting the mucous membranes of the respiratory tract and oral cavity by supporting the innate immune system.

Increased HE4 production in tissues is observed in a number of malignancies, particularly mesothelioma, lung cancer, breast cancer, kidney cancer, gastrointestinal cancer, endometrial cancer, and especially epithelial ovarian cancer. HE4 promotes tumor progression by enhancing tumor cell migration and adhesion, making it an important biomarker for monitoring and prognosticating the disease.

The HE4 tumor marker has a higher specificity than CA 125 in detecting epithelial ovarian cancer, especially in its early stages. It is recommended to combine HE4 with CA 125 to calculate the ROMA index – an assessment of the risk of the presence of a malignant process in the pelvis.

When and who needs the test?

  • differential diagnosis of pelvic masses;
  • epithelial ovarian cancer – for detection, monitoring of treatment effectiveness, and recurrence monitoring;
  • normal or elevated CA 125 levels;
  • assessing the risk of metastases;
  • benign ovarian diseases in combination with other markers;
  • suspected endometrial cancer, breast cancer, or other epithelial tumors.

Biological material

  • Venous blood

Preparing for a blood test

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:

  • an important condition for laboratory tests is to take blood on an empty stomach;
  • 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...

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2094. Tumor marker HE4

890 ₴

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