2081. Creatine kinase-MB (CPK-MB)

Creatine kinase (CK) is an enzyme involved in the function of muscles, the heart, and the nervous system. Creatine kinase-MB (CK-MB) is a form of the enzyme found predominantly in cardiac muscle cells. In ischemic and necrotic damage to cardiac tissue, large amounts of this enzyme are released into the bloodstream. Measurement of CK-MB is used in the diagnosis of myocardial infarction, angina pectoris, and other heart diseases.

CK-MB should be evaluated in conjunction with creatinine, AST, LDH, blood urea nitrogen (BUN), C-reactive protein (CRP), and troponin.

Creatine kinase-MB (CK-MB) is one of the forms of the creatine kinase enzyme. These forms include:

• creatine kinase-MM (CK-MM) (found in skeletal muscles and the heart) – approximately 60% of total creatine kinase activity;
• creatine kinase-MB (CK-MB) (found predominantly in the heart, but also present in small amounts in skeletal muscles) – approximately 40% of total creatine kinase activity.

An increase in the activity of this enzyme is most specific for myocardial infarction and is observed 4-8 hours after the onset of symptoms. Peak activity occurs 24-48 hours after symptom onset. By the third day, enzyme activity returns to normal values. There is a direct relationship between the CK-MB level and the extent of myocardial infarction.

• For the diagnosis of myocardial infarction.
• To monitor the course of myocardial infarction and assess the progression of myocardial necrosis.

• Venous blood

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules: