2079. Cardiolipin, IgG antibodies

Cardiolipin is a phospholipid found in blood plasma and is a component of the inner membrane of mitochondria. The determination of antibodies to cardiolipin is performed when antiphospholipid syndrome is suspected in the presence of venous thrombosis, pulmonary hypertension, migraine, seizures, or mental disorders.

An elevated level of IgG antibodies indicates a chronic course or a previously experienced process.

Recommended for the diagnosis of APS in pregnancy pathology, before starting oral contraceptives, and for assessing the risk of thrombosis.

As part of a comprehensive assessment, a complete blood count, biochemical blood test, coagulogram, and antibodies to beta-2-glycoprotein I are prescribed.

These are IgG autoantibodies directed against cardiolipin (diphosphatidylglycerol) – a phospholipid that forms intracellular membranes, primarily mitochondrial membranes.

An elevated level of anticardiolipin antibodies, regardless of the titer, is associated with an increased risk of arterial thrombosis, recurrent pregnancy loss, thrombocytopenia, and ischemic stroke.

An elevated IgG level correlates with an increased risk of ischemic stroke and its recurrence. An association between elevated IgG levels and recurrent pregnancy loss has also been established.

• For the diagnosis of antiphospholipid syndrome.
• For the differential diagnosis of thrombophilic conditions.
• For diagnosing the causes of recurrent pregnancy loss.
• For determining the causes of arterial and venous thrombosis.
• For the diagnosis of secondary antiphospholipid syndrome in systemic lupus erythematosus.

• Venous blood

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules: