2047. Phospholipids, IgG antibodies

Phosphatidylserine is one of the negatively charged phospholipids that are components of cell membranes. IgG antibodies to phosphatidylserine are a type of antiphospholipid antibodies. An elevated IgG level indicates chronic immune activity and may be a marker of thrombophilia.

The test for IgG antibodies to phospholipids (cardiolipin, phosphatidylserine, phosphatidylinositol, phosphatidic acid, and β-2-glycoprotein I) is used to screen for antiphospholipid syndrome (APS). This test helps identify disorders of hemostasis that may lead to venous thrombosis, pulmonary hypertension, migraines, seizures, and psychiatric disorders. An elevated level of IgG antibodies in the body indicates a chronic process.

In the event of a positive result for any phospholipid, a specific test for antibodies to that phospholipid should be performed. A complete blood count, blood chemistry panel, and coagulogram are also ordered as part of the assessment.

Exclusion of APS as one of the forms of thrombophilia (especially at a young age) in cases of:

• venous/arterial thrombosis (deep vein thrombosis, myocardial infarction, stroke, pulmonary embolism, infarction of internal organs, livedo reticularis, leg ulcers, transient cerebrovascular disorders, etc.);
• recurrent pregnancy loss, fetal loss syndrome at various stages of pregnancy, infertility, bleeding during pregnancy, development of preeclampsia and eclampsia, placental insufficiency with fetal growth restriction (FGR), premature placental abruption (PPA), history of stillbirth;
• before starting oral contraceptives (OCs), before prescribing hormone replacement therapy (HRT), and for monitoring during the use of these medications;
• in patients with cardiovascular disease to assess the risk of developing thrombotic complications or to determine their causes (stroke, myocardial infarction);
• in autoimmune diseases;
• in malignant neoplasms;
• if prolongation of activated partial thromboplastin time (aPTT) is detected in a coagulogram;
• in HELLP syndrome;
• in the case of a positive Wassermann reaction (RW);
• in thrombocytopenia and hemolytic anemia.

• Venous blood

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules: