Choose test
Where to pass the test?
Test from the National Health Service
Loyalty program
Nurse visit
For clients
  • Screening 40+
  • Wallet
  • Gift a Wallet
  • Special offers
  • Partner offers
  • Preparing a child for tests
  • Doctors’ consultations
  • Cytological passport
  • FAQ
  • “Be Healthy” portal
Laboratory
  • News
  • About us
  • Equipment
  • Licenses and certificates
  • Leadership
  • Career
  • Contacts
For doctor
  • Information for doctors
Business
  • Tissue diagnostics
  • Cooperation with Synevo
  • Business Cabinet
  1. Home
  2. Panels
  3. Therapeutic drug monitoring
  4. 1154. Valproic acid

All test sections

Choose the category you’re interested in

TOP tests

What to check

Heart and blood vesselsSugar and metabolismThyroid glandImmunityInfectionsWomen's and men's healthTumor markersLiver and kidneysVitamins and trace elementsAllergensBlood type and Rh factorGenetic testsSkin, Hair, and Nails

Diseases

Cardiovascular diseasesDiabetes mellitus and metabolismThyroid gland and hormonal disordersInfectious diseasesAnemia and blood diseasesAllergies and immunological conditionsUrogenital infections and STDsTORCH infectionsPathology of pregnancyOncology and tumor screeningObesity and endocrine disordersHepatitis and liver diseasesGastroenterology and the gastrointestinal tractInflammatory and rheumatic diseasesRenal failure and kidney diseasesNeurological disordersTuberculosisWorms and parasitic infestationsGenetic diseases and mutation carriageCeliac disease and food intoleranceHealth of skin, hair and nails

For whom

For womenFor menFor childrenFor the elderlyWhen planning a pregnancy For pregnant womenBefore surgeryFor athletes and active peopleFor beautyFor vegetarians and vegans

Check-up

Women'sMen'sChildren'sFor the elderlyCardiovascularHormonalMetabolism and diabetesSkin, Hair and Nail HealthImmune and InfectiousOncologyVitamins and MineralsReproductive HealthAnnual PreventiveSpecializedAdvanced

Panels

General clinicalThyroid panelPhosphorus-calcium metabolismReproductive panelHypothalamic-pituitary-adrenal axisCarbohydrate metabolismPrenatal diagnosticsKaryotypingOncology panelOther infectionsHepatitisTorch infectionsUrogenital infectionsCoronavirus SARS-CoV-2Parasitic infectionsHivLyme disease (borreliosis)Helicobacter pyloriTuberculosisAutoimmunological panelImmunological causes of infertilityCeliac diseaseRheumatological panelGeneral immunologyAntiphospholipid syndromeBacteriological panelCytological panelPathomorphological panelBiochemical panelVitaminsAnemiaCardiovascular disease markersAcute phase markersTherapeutic drug monitoringHeavy metalsAmino acids. Organic acidsGenetic panelScreening packagesAllergological panel

Biomaterial

Blood ScrapingUrineFeces Sperm SalivaProstate secretSmear / Bacterial culturePlacenta / amniotic fluidBile / breast milkLiquorPathomorphologyCytology on glass

1154. Valproic acid

1154. Valproic acid

Turnaround time (days): 1

630 ₴

Description

Valproic acid is an effective medication for the treatment of absence seizures, partial seizures, and generalized tonic-clonic seizures. It may be used as monotherapy or in combination with other antiepileptic drugs.

This test is used to determine the concentration of valproic acid in the blood and to guide the selection and adjustment of the valproic acid dosage in patients with seizure disorders.

Pharmacotherapeutic Group
Antiepileptic drugs. Fatty acid derivatives.

Pharmacodynamics
Valproic acid is a long-acting anticonvulsant. It inhibits GABA transaminase, thereby reducing the biotransformation (inactivation) of gamma-aminobutyric acid (GABA), stabilizing and increasing its concentration in the central nervous system. It enhances central GABAergic activity, particularly stress-limiting inhibitory processes, thereby reducing neuronal excitability and the seizure susceptibility of the motor areas of the brain.

Pharmacokinetics
Valproic acid is metabolized primarily in the liver. The mean plasma elimination half-life (T½) in adults is 10.6 hours (although it may range from 5 to 20 hours), which serves as the basis for a twice-daily dosing regimen. The drug is excreted primarily by the kidneys.

Overdose
At plasma concentrations exceeding the upper therapeutic limit by five- to six-fold, nausea, vomiting, and dizziness may occur. In cases of significant overdose, coma (superficial or deep) may develop, accompanied by muscle hypotonia, hyporeflexia, myositis, respiratory depression, and manifestations of metabolic acidosis. Intracranial hypertension associated with cerebral edema and circulatory collapse/shock may also occur. Very high plasma concentrations may provoke seizures. Due to the sodium content of valproate formulations, overdose may also result in hyponatremia.

When and who needs the test?

  • For monitoring total valproic acid concentrations during therapy.
  • For assessing patient adherence to treatment (treatment compliance).
  • For evaluating potential toxicity.

Biological material

  • Venous blood

Preparing for a blood test

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:

  • an important condition for laboratory tests is to take blood on an empty stomach;
  • 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...

1154. Valproic acid

630 ₴

Information service

0 800 60 55 00

Free from mobile and stationary operators in Ukraine (except for the temporarily occupied territories)

Our social media

Media inquiries contacts

press@synevo.ua

About Us

About us
Career
News
Contacts

Customers

Choose test
Where to pass the test?
Get results
Special offers
“Be Healthy” portal

Legal information

Public contract
Loyalty program rules
Financial statements
Licenses and certificates
Tender
Legal conditions of special offers
Providing services to minors
Synevo, 2026