1149. free β-hCG (prenatal diagnosis)

Free β-hCG is a subunit of human chorionic gonadotropin, a fetal hormone. It is used for early diagnosis of pregnancy, its complications, and hCG-related diseases, as well as for assessing the risk of fetal chromosomal abnormalities during the first trimester of prenatal screening. It is an important indicator of pregnancy progression and its potential complications.

Free β-subunit of human chorionic gonadotropin (β-hCG) is a component of a specific hormone synthesized by the embryonic membranes after implantation. In the first trimester of pregnancy, its level in a woman's blood is a key biomarker for early assessment of pregnancy status.

β-hCG testing is widely used in prenatal diagnosis to identify the risk of fetal chromosomal abnormalities, such as trisomy 21 (Down syndrome) and trisomy 18 (Edwards syndrome). The test also helps detect ectopic pregnancies and assess embryo viability, threatened miscarriage, fetal growth restriction, or placental dysfunction.

Ectopic β-hCG activity can also be a sign of trophoblastic neoplasms (e.g., hydatidiform mole, choriocarcinoma) or conditions associated with impaired secretion of this hormone.

• Pregnant women in the first trimester (10-13 weeks + 6 days) as part of first-trimester prenatal screening.
• If an ectopic or multiple pregnancy is suspected.
• To monitor the progress of pregnancy, especially in cases of risk of miscarriage, fetal growth restriction, or placental insufficiency.
• For follow-up after termination of pregnancy.
• In cases of menstrual irregularities (amenorrhea).
• For the diagnosis and monitoring of trophoblastic neoplasms.

• Venous blood

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules: