2436. Bordetella pertussis toxin (cough toxin), IgG antibodies

The test detects IgG antibodies to the toxin of Bordetella pertussis, the main causative agent of whooping cough. These antibodies are formed after the disease or in response to vaccination.

Whooping cough is an acute bacterial respiratory disease caused by Bordetella pertussis. It is transmitted by airborne droplets and is highly contagious, especially in groups and among unvaccinated individuals.

The classic symptoms of whooping cough include coughing fits, loud, deep inhalations between coughs, and post-cough vomiting. The course of the disease is divided into three phases: catarrhal (with acute respiratory viral infection symptoms), spasmodic (with a typically prolonged cough with paroxysms), and convalescence.

It is especially dangerous for infants and individuals with weakened immune systems. IgG antibodies begin to synthesize 3-4 weeks after infection or vaccination. Detection of IgG indicates a history of the disease or the development of a post-vaccination immune response, but does not allow the precise timing of exposure to the pathogen to be determined.

• For children and adults with suspected whooping cough (paroxysmal cough lasting more than 3 weeks).
• For differential diagnosis with acute respiratory infections.
• For individuals who have had contact with patients with whooping cough.
• For the diagnosis of post-infection and post-vaccination immune responses.

• Venous blood

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules: