2369. Allergen. Drug. Basophil activation test (CD203+)
Important information
The test can be taken Monday through Friday according to the blood
collection schedule of the selected laboratory department.
- You must bring a liquid injectable medication in its original packaging
(ampoule, vial, etc.) for which allergy testing is required.
- Medication requirements:
pharmaceutical form (liquid, injectable, sterile) with clear labeling of the
medication itself.
- Medications in the
following forms are not accepted:
suspension, syrup, emulsion, drops, tincture, infusion, mixture, capsule,
tablet, powder, granule, dragee, cream, ointment, gel, paste, aerosol, and
other forms.
Description
The basophil activation test (BAT) is a modern laboratory method that helps determine whether you have an allergy to injectable medications (anesthetics, nonsteroidal anti-inflammatory drugs, analgesics, antibiotics, serums, etc.). It also allows you to assess the risk of severe allergic reactions (angioedema, anaphylaxis) before using the drug, meaning you can determine its safety in advance. Unlike provocative tests, it does not require injecting the drug into the body and therefore cannot cause an allergic reaction. The main advantage of the test is that it detects both obvious and latent allergic reactions and comprehensively determines individual sensitivity to all components of the drug.
To take the test, you must bring the desired medication (in liquid form for injection) to the laboratory and provide a venous blood sample.
Important information!
The test can be taken Monday through Friday according to the blood collection schedule of the selected laboratory department.
Requirements for the drug:
- The drug must be an injection solution (in its original packaging – ampoule, vial, syringe, or automatic injection cartridge);
- Sterile (undamaged) packaging;
- Clear labeling with the drug name.
These requirements ensure the accuracy of the test and the reliability of the results.
When and who needs the test?
The basophil activation test (CD203+) is recommended for:
- patients at elevated risk of drug allergy, particularly in the presence of multiple sensitization, chronic diseases, or immunodeficiency states;
- individuals who have previously experienced anaphylactic reactions to medications or pronounced allergic responses following injectable drug formulations (antibiotics, anaesthetics, NSAIDs, analgesics, vitamins, sera, contrast agents, etc.);
- clarification of the causes of drug reactions when other diagnostic methods (IgE testing, skin tests) do not yield conclusive results;
- prior to prescribing a potentially allergenic drug – to enable individualised selection of safe therapy;
- assessment of anaphylaxis risk, including the possibility of bronchospasm, angioedema, and systemic reactions.
Test results may be influenced by medication use, acute inflammatory processes, stress, physical exertion, and non-compliance with preparation requirements prior to blood collection.
Biological material
- Venous blood
Preparing
To eliminate factors that may affect test results, we recommend following these preparation guidelines:
- fasting blood sample collection is an important requirement for laboratory testing;
- for 6 to 12 hours before the test, you should refrain from eating, drinking alcohol, smoking, and limit physical activity....