2356. Allergen. Nonsteroidal anti-inflammatory drug. Ibuprofen (c78), IgE antibodies
Turnaround time (days): 5
450 ₴
Description
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used medications in global medical practice. At the same time, they are also a frequent cause of hypersensitivity reactions to pharmaceuticals. The main mechanisms of NSAID-induced allergic adverse reactions may be associated with cyclooxygenase-1 (COX-1) inhibition and IgE-mediated immune responses. Modern literature describes four types of pseudoallergic reactions and two types of true allergic reactions to NSAIDs.
Ibuprofen allergy may lead to a variety of symptoms, including skin rashes, itching, swelling, and respiratory issues (such as bronchospasm or anaphylaxis). In addition to these reactions, ibuprofen use can aggravate the course of bronchial asthma. This is due to its potential effect on the production of leukotrienes – substances that cause narrowing of the airways. The likelihood of allergic reactions to ibuprofen is higher among individuals sensitive to aspirin.
In clinical practice, it can be difficult for physicians to distinguish between allergic and pseudoallergic reactions to ibuprofen. To avoid severe responses to allergen exposure, it is advisable to perform a blood test to assess IgE levels. An elevated level of ibuprofen-specific immunoglobulin E indicates sensitization of the body to this substance. The results obtained support the diagnosis of type I (immediate-type) allergy. The analysis is performed using the Dr. Fooke method (ELISA).
When and who needs the test?
- Suspected allergic reaction following ibuprofen intake.
- Symptoms of intolerance or allergy after ibuprofen use, such as itching, rash, swelling, or breathing difficulties.
- Planning NSAID-based therapy in patients with an increased risk of allergy.
Biological material
- Venous blood
Preparing for a blood test
In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:
- an important condition for laboratory tests is to take blood on an empty stomach.
- 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...