2353. Allergen. Antibiotic. Tetracycline (c59), IgE antibodies
Description
Many people experience adverse reactions after taking various medications. However, among all side effects, true drug allergy accounts for approximately 10%. Any medication can potentially trigger an allergic reaction, but it most commonly results from the use of antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), or local anesthetics.
A drug allergy may be caused by:
- genetic predisposition or the presence of another type of allergy;
- prolonged use of the medication;
- simultaneous use of multiple medicinal products;
- long-term contact with medications (in this case, healthcare professionals, pharmacists, and medical staff are considered at risk).
The diagnosis of antibiotic allergy includes skin prick tests, intradermal administration of the drug, provocation testing, and the detection of drug-specific IgE antibodies. In cases of immediate-type allergic reactions, skin and provocation tests can cause pronounced allergic symptoms, including potentially life-threatening reactions. An increased level of specific IgE to a particular antibiotic indicates sensitization of the body to that substance. The results obtained assist in diagnosing type I (immediate) allergy. The test is performed using the Dr. Fooke method (ELISA).
When and who needs the test?
- to detect increased sensitivity to tetracycline;
- to confirm or rule out the presence of an allergy to tetracycline;
- to assess the possibility of using tetracycline in individuals prone to allergic reactions, or in those with a history of allergy to other antibiotics in the tetracycline group;
- to determine the reaction to tetracycline prior to conducting skin and provocation tests;
- to examine individuals who developed typical signs of allergy after taking tetracycline.
Biological material
- Venous blood
Preparing for a blood test
In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:
- an important condition for laboratory tests is to take blood on an empty stomach.
- 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...