2225. Liver profile (BlotAnalisis)
Description
A liver profile is a comprehensive autoimmune examination of the liver, which is aimed at identifying the main laboratory diagnostic markers of autoimmune liver damage using immunoblotting.
Autoantibodies to components of liver cells and tissues
are directed to various components of cells and tissues of the human body. The
package includes the determination of 5 indicators: IgG antibodies to AMA-M2;
M2-3E/LKM-1/LC-1/SLA+LP.
AMA-M2 is an autoantibody directed against the
mitochondrial antigens of liver cells. These autoantibodies are formed in
autoimmune liver pathologies, are detected in 95% of patients with biliary
cirrhosis, are found in the case of CTD, and in the case of liver damage due to
drugs.
IgG antibodies to mitochondrial antigen M2-3E are
antibodies to the main epitope of type 2 antimitochondrial antibodies. They
occur together with AMA-M2 in patients with primary biliary cirrhosis; their
detection increases the sensitivity of the examination.
Antibodies to the microsomal fraction of the liver and
kidneys (anti-LKM-1) are autoantibodies directed against enzymes of hepatocytes
and renal tubular epithelium. They are studied to diagnose autoimmune hepatitis
and monitor its treatment.
Cytosolic antigen type 1 (LC-1) antibodies and soluble
liver/pancreas antigen (SLA/LP) antibodies are also diagnostic markers for AIH.
They refer to laboratory indicators of the second line of diagnosis when
first-line antibodies are not detected: anti-smooth muscle antibodies,
antinuclear antibodies and antibodies to LKM-1.
When and who needs the test?
It is recommended to take this package test for patients with clinical manifestations of liver damage with suspected autoimmune nature of the disease.
Biological material
- Venous blood
Preparing for a blood test
In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:
- an important condition for laboratory tests is to take blood on an empty stomach.
- 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...