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  3. Antiphospholipid syndrome
  4. 2117. Phosphatidylserine, IgM antibodies

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2117. Phosphatidylserine, IgM antibodies

2117. Phosphatidylserine, IgM antibodies

Turnaround time (days): 2

1290 ₴

Description

Phosphatidylserine is one of the negatively charged phospholipids that are components of cell membranes. Antibodies to phosphatidylserine are a type of antiphospholipid antibodies. They are considered one of the possible causes of antiphospholipid syndrome.

The use of an IgM antibody test for phosphatidylserine increases the sensitivity of laboratory diagnosis of antiphospholipid syndrome in cases of infertility.

Phosphatidylserine is a negatively charged phospholipid that is a component of cell membranes. Testing for IgM antibodies to phosphatidylserine is performed in the presence of venous thrombosis, pulmonary hypertension, migraines, seizures, and psychiatric disorders.

It is recommended for the diagnosis of antiphospholipid syndrome when specific tests for APS are negative and for identifying the causes of thrombotic complications.

Before this test, tests for antibodies to β-2-glycoprotein I, cardiolipin, and lupus anticoagulant, as well as a coagulogram, are performed.

When and who needs the test?

Exclusion of APS as one of the forms of thrombophilia (especially at a young age) in cases of:

  • negative results for the laboratory criteria of APS (lupus anticoagulant [LA], anticardiolipin antibodies [aCL], and anti-β2-glycoprotein I antibodies);
  • venous/arterial thrombosis (deep vein thrombosis, myocardial infarction, stroke, pulmonary embolism, infarction of internal organs, livedo reticularis, leg ulcers, transient cerebrovascular disorders, etc.);
  • recurrent pregnancy loss, fetal loss syndrome at various stages of pregnancy, infertility, bleeding during pregnancy, development of preeclampsia and eclampsia, placental insufficiency with fetal growth restriction (FGR), premature placental abruption (PPA), history of stillbirth;
  • before starting oral contraceptives (OCs), before prescribing hormone replacement therapy (HRT), and for monitoring during the use of these medications;
  • in autoimmune diseases;
  • in any oncological disease, thrombocytopenia, or hemolytic anemia.

Repeat testing is recommended after an initially positive result (after 12 weeks).

Biological material

  • Venous blood

Preparing for a blood test

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:

  • an important condition for laboratory tests is to take blood on an empty stomach;
  • 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...

2117. Phosphatidylserine, IgM antibodies

1290 ₴

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