2109. Tissue transglutaminase, IgA antibodies
Description
Celiac disease is an autoimmune disease that affects the epithelium of the small intestine because of the immune system's response to dietary gluten (a protein in cereals). Symptoms of the disease: diarrhea, weight loss, excretion of fat in the feces, iron deficiency anemia, skin rashes, drowsiness, flatulence.
This is the first line test for diagnosing celiac disease in the presence of symptoms with normal total IgA levels and for monitoring a gluten-free diet. In the complex, it is possible to prescribe an test for total IgA, IgA to deaminated gliadin peptides (especially in children under 2 years of age) and endomysium.
When and who needs the test?
- screening study of patients with suspected celiac disease (with a typical and atypical clinical picture), persons with an increased risk of developing the disease (aggravated family history of celiac disease, preliminary diagnosis, carriers of HLA alleles - DQ2 and / or DQ8);
- screening study for suspected dermatitis herpetiformis in combination with the study of antibodies to endomysium- monitoring of process activity, assessment of adherence to a gluten-free diet, control of a gluten-free diet in patients with dermatitis herpetiformis and celiac disease.
Biological material
- Venous blood
Preparing for a blood test
In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:
- an important condition for laboratory tests is to take blood on an empty stomach.
- 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...
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