All test sections
Choose the category you’re interested in
What to check
Diseases
For whom
Check-up
Panels
Biomaterial
2109. Tissue transglutaminase, IgA antibodies
Description
The active phase of celiac disease is associated with elevated blood levels of IgA antibodies to tissue transglutaminase (tTG) and endomysium (IgA-EMA). Tissue transglutaminase (tTG) is a calcium-dependent enzyme that is widely distributed throughout the body's tissues and is released in response to inflammation, playing an important role in the pathogenesis of celiac disease.
The IgA-tTG level is a key diagnostic criterion and is measured not only to confirm celiac disease but also to monitor the effectiveness of a gluten-free diet, as antibody levels decrease when the diet is followed.
When and who needs the test?
- Screening of patients with suspected celiac disease (with a typical or atypical clinical presentation) and individuals at increased risk of developing the disease (a family history of celiac disease, a preliminary diagnosis, carriers of HLA-DQ2 and/or HLA-DQ8 alleles).
- Screening in patients with suspected dermatitis herpetiformis, in conjunction with anti-endomysial antibody testing, for monitoring disease activity, assessing adherence to a gluten-free diet, and monitoring compliance with a gluten-free diet in patients with dermatitis herpetiformis and celiac disease.
Biological material
- Venous blood
Preparing for a blood test
In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:
- an important condition for laboratory tests is to take blood on an empty stomach;
- 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...
Cheaper in a package