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  3. 2015. Hepatitis D virus (HDV), total antibodies

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2015. Hepatitis D virus (HDV), total antibodies

2015. Hepatitis D virus (HDV), total antibodies

Turnaround time (days): 2

550 ₴

Description

Hepatitis D virus (HDV) is a 'defective' virus containing a ring-shaped single-stranded RNA thread and capable of replication only in the presence of hepatitis B virus. HDV builds its shell from HBs antigen and is unable to fully reproduce without hepatitis B virus. When infected with hepatitis D virus during existing viral hepatitis B, superinfection occurs, which is characterized by a wave-like course. Coinfection with viral hepatitis D reduces the likelihood of a favorable response to antiviral therapy. In 5%, liver damage quickly progresses to cirrhosis, which, as a consequence, increases the risk of developing hepatocellular carcinoma. HDV infection is diagnosed with a high level of total immunoglobulins (IgG and IgM) against HDV, which is confirmed by the detection of HDV RNA in the blood serum.

When and who needs the test?

  • screening for HDV infection;
  • detection of co-infection or superinfection with HDV (in combination with other HBV markers and HDV PCR);
  • fulminant hepatitis;
  • examination of recipients of donor organs and patients on hemodialysis;
  • differential diagnostics of mixed hepatitis;
  • chronic liver diseases: cirrhosis, exacerbation of chronic hepatitis B;
  • increased transaminases in HBsAg carriage.

Important notes

Hepatitis D testing is prescribed after detection of HBs antigen. Reproduction of the hepatitis D virus inhibits the replication of the hepatitis B virus in liver cells (the phenomenon of viral interference). As a result, many serological markers may not be detected in the blood of the person being examined or their concentration may be reduced.

Biological material

  • Venous blood

Preparing for a blood test

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:

  • an important condition for laboratory tests is to take blood on an empty stomach.
  • 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...

2015. Hepatitis D virus (HDV), total antibodies

550 ₴

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