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  2. 1180. Protein C (activity)

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1180. Protein C (activity)

1180. Protein C (activity)

Turnaround time (days): 14

3100 ₴

Description

Protein C is a vitamin K-dependent glycoprotein synthesized in the liver. It circulates in the blood in an inactive form and is activated by the thrombin-thrombomodulin complex. Activated protein C (APC) is a natural anticoagulant: in the presence of ionized calcium, phospholipids, and the cofactor protein S, it inactivates coagulation factors Va and VIIIa, thereby inhibiting thrombin formation.

Protein C, along with protein S, are key components of the anticoagulant system that limits excessive blood clotting. Protein C constantly circulates in the blood in an inactive state. It is activated by the action of the thrombin-thrombomodulin complex on the surface of intact endothelial cells and platelets. In its active form, protein C partially destroys and inactivates non-enzymatic coagulation factors Va and VIIIa.

Its activity does not increase during inflammation (it is not an acute phase protein), but decreases with liver damage, vitamin K deficiency, nephrotic syndrome, disseminated intravascular coagulation (DIC), and under the influence of anticoagulants or hormonal drugs.

Types of deficiency:

  • Type I (quantitative) – decreased protein C concentration;
  • Type II (qualitative) – normal levels, but decreased functional activity.

Genetic deficiency of protein C (heterozygous or homozygous) leads to an increased risk of venous thrombosis and pulmonary embolism.

Protein C does not function effectively without protein S, so both markers are often tested together.

Important: Protein C levels are recommended to be measured as part of a comprehensive laboratory assessment of other indicators of the blood coagulation and anticoagulation systems.

When and who needs the test?

When?

  • During a comprehensive diagnosis of thrombophilia.
  • In the presence of episodes of arterial or venous thrombosis without obvious causes.
  • To prevent recurrent thrombosis after an acute thrombotic event.
  • During a comprehensive diagnosis of thrombotic complications during pregnancy.

Who should use it?

  • Young people (under 50 years) with a familial history of thrombosis.
  • Patients with recurrent thrombosis.
  • Individuals with thromboembolic complications without other obvious causes.

Biological material

  • Venous blood

Preparing for a blood test

In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:

  • an important condition for laboratory tests is to take blood on an empty stomach;
  • 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...

1180. Protein C (activity)

3100 ₴

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