1106. TSH receptor, IgG antibodies (Anti-TSHR)
Description
Thyroid-stimulating hormone receptor antibodies (TSH receptor antibodies) are produced when the immune system mistakenly recognizes TSH receptors as foreign agents. These antibodies bind to TSH receptors located on thyroid cells and mimic the action of thyroid-stimulating hormone. This causes an increase in thyroid hormone levels in the blood, leading to hyperthyroidism.
This test helps diagnose Graves’ disease, differentiate it from other thyroid conditions with elevated thyroid function, and predict the likelihood of disease relapse.
For the most accurate assessment, it is best to measure these antibodies alongside TSH, free T4, and free T3.
When and who needs the test?
Differential diagnosis of:
- thyrotoxicosis during pregnancy
- Graves’ disease versus various forms of destructive thyrotoxicosis
- subclinical thyrotoxicosis with diffuse goiter
- euthyroid endocrine ophthalmopathy multinodular toxic goiter with hot nodules
- neonatal hypothyroidism induced by maternal antibodies, with normally
- located thyroid gland
- neonatal thyrotoxicosis due to transplacental transfer of TSH receptor
- antibodies, with possible fetal thyroid involvement
- prediction of relapse in Graves’ disease
Biological material
- Venous blood
Preparing for a blood test
In order to exclude factors that may affect the test results, we recommend to follow the preparation rules:
- an important condition for laboratory tests is to take blood on an empty stomach.
- 6-12 hours before the test, you should avoid eating, drinking alcohol, smoking, and limit physical activity. Drinking...
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